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Objective: To compare the effects of different methods on the glucose treat-to-target time, glucose fluctuation, hypoglycemia and insulin doses in the type 2 diabetic patients treated by insulin bump, and to find the best method to make the glucose to reach the standand level safely, fast and effectively in the type 2 diabetic patients treated by insulin bump. Methods; Sixty hospitalized type 2 diabetic patients inadequatly controlled by premix insulin treatment were randomly divided into convention group (n=20), Bolus Wizard group (n=20), and Bolus Wizard combined with monitoring (combination) group (n-20) according to the random number grouping method. The insulin doses of the patients in convention group were adjusted according to the glucose monitoring of fingertip and the doctor' s experiences; the insulin doses of the patients in Bolus Wizard group were adjusted according to the Bolus Wizard software in insulin bump, and the glucose monitoring of fingertip; the insulin doses of the patients in combination group were adjusted according to the Bolus Wizard software combined with real time continuous glucose monitoring system (RTCGM). The level of fingertip glucose was tested. The standard deviation of blood glucose (SDBG) and largest amplitude of glycemic excursion (LAGE) were used to evaluate the glucose fluctuation of the patients in various groups. The treat-to-target time, glucose fluctuation, hypoglycemia and daily insulin doses of the patients in various groups were recorded. Results: Compared with convention group, the treat-to-target time of the patients in Bolus Wizard group was decreased (t= 2. 30, P<0. 05); compared with Bolus Wizard group, the treat-to-target time of the patients in combination group was decreased (t=3. 50, P< 0.05). On the 3rd day of treatment, compared with convention group, the SDBG and LAGE of the patients in Bolus Wizard group were decreased (tSDBC; = 3. 11, tLAGE = 2.54, P<0.05); compared with Bolus Wizard group, the LAGE of the patients in combination group was decreased (tlage = 2. 47, P<0. 05). There were no significant differences in the incidence of total hypoglycemia events (χ2 = 2. 192, P=0. 532), significant hypoglycemia events (χ2= 2.765, P=0. 322) and nocturnal hypoglycemia events (χ2 = 2.192, P=0. 532) among the patients in various groups; there were no significant differences in the average insulin dosage (F= 2. 102, P=0. 131), the non-basic insulin dosage (χ2 = 2.328, P=0. 107) and the percentage of non-basic insulin (χ2= 2.104, P=0. 131) among the patients in various groups. Conclusion: Bolus Wizard software combined with real-time dynamic RTCGM has better effect in the treatment of type 2 diabetes without increasing the risk of hypoglycemia and insulin dosage.
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This study was aimed to observe the clinical efficacy of Xi-Jiao Di-Huang (XJDH) decoction in the treatment of episcleritis and to provide references for its clinical treatment.A total of 48 episcleritis cases from January to December 2015 were randomly divided into two groups,with 26 cases in the observation group and 22 cases in the control group.The same conventional drug therapy was given to both groups.XJDH decoction was also given to the observation group.Clinical efficacy and recurrence rate of both groups were compared.The results showed that the total effective rate of the observation group was 92.30％,which was obviously better than 72.72％ in the control group,with statistical significance (P ＜ 0.05).The recurrence rate of the observation group was 26.90％,which was obviously better than 40.90％ in the control group,with statistical significance (P ＜ 0.05).It was concluded that XJDH decoction combined with modern medicine treatment in the treatment of episcleritis achieved better clinical curative effect with lower recurrence rate.It provided positive guidance in the clinical treatment of episcleritis.
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OBJECTIVE: To evaluate the effects of Xuefu Zhuyu Decoction (XFZYD) on functions of vascular endothelium in patients with unstable angina pectoris (UAP). METHODS: Fifty patients with UAP were randomly divided into two groups: XFZYD-treated group with 32 cases and control group with 18 cases. The patients in the control group were given regular therapy, while the patients in the XFZYD-treated group were given XFZYD additionally on the basis of regular therapy. All patients in both groups were treated for 8 weeks. Then the contents of serum endothelin (ET), nitric oxide (NO), soluble vascular cell adhesive molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were examined by radioimmunoassay, enzymic method and enzyme-linked immunosorbent assay (ELISA) respectively. RESULTS: The total response rate in the XFZYD-treated group was 93.75%, which was significantly higher than 66.67% in the control group (P<0.05). The contents of serum ET, sVCAM-1 and sICAM-1 in the XFZYD-treated group were much lower than those in the control group (P<0.01), while the content of serum NO was obviously higher than that in the control group (P<0.01). CONCLUSION: XFZYD can improve the functions of vascular endothelium by lowering the levels of endothelium-derived contracting substances, enhancing the levels of endothelium-derived relaxing substances, and reducing the cell adhesions, and hence to raise the therapeutic effects on UAP.
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Objective[WT5”BZ] To improve the surgical result of circumferential mixed hemorrhoids by using a new technique.[WT5”HZ]Method[WT5”BZ] 371 cases of circumferential mixed hemorrhoids were divided into two groups treated respectively by anal pad preserving(with intact dentate line) respective resection of the internal and external hemorrhoids (RR group) and those treated with routine approach of stripping off the varicose masses of the external hemorrhoids and ligating the internal (control group).[WT5”HZ]Results[WT5”BZ] (1)Cure rates were 84 7%(166/196) in RR group and 74 8%(131/175) in controls, P 0 05.(4) Postoperative complications: a) Postoperative anal pain:mild in 75,moderate in 53 and severe in 68 cases in RR compared with mild in 28,moderate in 47and severe in 100 cases in controls, P 0 05. c) Postoperative urinary dysfunction:26 5%(52/196) in RR and 44 6%(78/175) in controls respectively. d) Tenesmus:7 7%(15/196) in RR and 21 1%(37/175) in controls, P